5-Aminolevulinic acid formation from glutamate via the C5pathway inClostridium thermoaceticum
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منابع مشابه
Alternative Routes for the Synthesis of 5-Aminolevulinic Acid in Maize Leaves : II. Formation from Glutamate.
Intact plastids from greening maize (Zea mays L.) leaves converted [(14)C]glutamate and [(14)C]2-ketoglutarate (KG) to [(14)C]5-aminolevulinic acid (ALA). Glutamate appeared to be the immediate precursor of ALA, while KG was first converted to glutamate, as shown by the effect of various inhibitors of amino acid metabolism. Plastids from greening leaves contained markedly higher activity as com...
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5-Aminolevulinic acid accumulated in the culture medium when Agmeneflum quadplicatum strain PR-6 was incubated in the presence of levulinic acid, a competitive inhibitor of 8-aminolevulinic acid dehydratase, and specifically labeled glutamate and glycine. The 8-aminolevulinic acid was purified using Dowex 50W-X8 and cleaved by periodate to yield succinic acid and formaldehyde. The distribution ...
متن کامل5-aminolevulinic acid from photosynthetic bacteria and its applications
Tangprasittipap, A. and Prasertsan, P. 5-aminolevulinic acid from photosynthetic bacteria and its applications Songklanakarin J. Sci. Technol., 2002, 24(4) : 717-725 This paper gives an overview on ALA production by photosynthetic bacteria concerning biosynthesis and regulation as well as its application as herbicide, insecticide and growth stimulator. Recent medical applications in the field o...
متن کاملEngineering Corynebacterium glutamicum to produce 5-aminolevulinic acid from glucose
BACKGROUND Corynebacterium glutamicum is generally regarded as a safe microorganism and is used to produce many biochemicals, including L-glutamate. 5-Aminolevulinic acid (ALA) is an L-glutamate derived non-protein amino acid, and is widely applied in fields such as medicine and agriculture. RESULTS The products of the gltX, hemA, and hemL genes participate in the synthesis of ALA from L-glut...
متن کاملPorphyrin Synthesis from 5-Aminolevulinic Acid in Patients with Glioma
The molecule 5-aminolevulinic acid (5-ALA) is a substrate for a heme synthesized in cells us‐ ing succinyl CoA and glycine. Initially, 5-ALA is converted to porphobilinogen (PBG), and the metabolism progresses by the action of PBG deaminase, and its product is incorporated into the mitochondria via uroporphyrinogen and coproporphyrinogen by an enzymatic reaction and transformed into protoporphy...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1988
ISSN: 0014-5793
DOI: 10.1016/0014-5793(88)80591-x